Faculty

Graduate students may complete their research under the direction of the members of the Biochemistry Graduate Studies Committee (GSC)

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Eric V. Anslyn
Distinguished Teaching Professor in Chemistry & Biochemistry
Norman Hackerman Professorship in Chemistry
Email
web site
Our research is oriented at developing artificial enzymes and sensors by synthetic and combinatorial library methods. Our synthetic projects are targeted to phosphodiester hydrolysis, enolate alkylations, and Eric V. Anslyn

Dean R. Appling
Professor in Chemistry & Biochemistry
Lester J. Reed Professor In Biochemistry
Email
web site
My laboratory studies the organization and regulation of metabolic pathways in eukaryotes. Eukaryotic cells are composed of many different compartments, such as cytoplasm, mitochondria, and nuclei. Although ea Dean R. Appling

Karen S. Browning
Associate Professor in Chemistry & Biochemistry
Chairman, Cell & Molecular Biology Graduate Program and Director Dual Degree MD/PhD Program
Email
web site
My research focuses on the initiation of protein synthesis in higher plants. We are seeking a molecular description of the process in which initiation factors (eIF4A, eIF4B, eIF4F, eIF3, eIF2 and PABP) select, Karen S. Browning

Richard Crooks
Professor in Chemistry & Biochemistry
Robert A. Welch Chair in Materials Chemistry
Email
web site
Parallel replication of DNA and RNA arrays. We recently discovered a new method for replicating nucleic acid microarrays. Such arrays are presently used for genomic analysis, and within the next few years are e Richard Crooks

Kevin Dalby
Associate Professor of Pharmacy, Medicinal Chemistry 

Email
web site

Cancer is most commonly caused by the development of aberrant cell signaling pathways. Modern pharmaceutical research thus seeks a clear understanding of these pathways in efforts to treat this all too prevale Kevin Dalby

Andy Ellington
Professor in Chemistry & Biochemistry
Wilson M. and Kathryn Fraser Research Professor In Biochemistry
Email
web site
The Ellington lab is primarily interesting in the evolutionary engineering of molecules, pathways, and organisms, and the application of these efforts to real world problems. In particular, we evolve functiona Andy Ellington

Walter Fast
Associate Professor of Pharmacy, Medicinal Chemistry 

Email
web site

We are interested in merging protein engineering technologies with more classical biochemical approaches in the investigation and manipulation of three enzyme systems: 1. Quorum sensing, a “language” that s Walter Fast

George Georgiou
Professor in Chemical Engineering
Cockrell Family Regents Chair in Engineering #9
Email
web site
Dr. Georgiou’s group is working on both biotechnology and mechanistic biology problems. In biotechnology, his group is focusing on the development of protein engineering and combinatorial library screening te George Georgiou

Marvin Hackert
Professor in Chemistry & Biochemistry
William Shive Centennial Professor In Biochemistry
Email
web site
Our research focuses on understanding function of proteins in relationship to their three-dimensional structures. Antizyme and antizyme inhibitor are regulatory proteins of ornithine decarboxylase that initiate Marvin Hackert

David Hoffman
Associate Professor in Chemistry & Biochemistry 

Email
web site

Biophysical methods such as nuclear magnetic resonance (NMR) spectroscopy and x-ray crystallography are extensively used in our investigations of protein and RNA structure and function. Current work includes t David Hoffman

Jon Huibregtse
Professor in Molecular Genetics & Microbiology
Graduate Advisor, Cell and Molecular Biology Graduate Program
Email
web site
The Huibregtse lab studies the biochemistry of the ubiquitin proteolysis system, a major pathway for degradation of proteins in eukaryotic cells. Our interest in this pathway arose from study of human papilloma Jon Huibregtse

Brent Iverson
Distinguished Teaching Professor in Chemistry & Biochemistry
Warren J. and Viola Mae Raymer Professor
Email
web site
Antibody and enzyme engineering with an emphasis on creating better methods for improving protein function. Several new technologies have been developed and patented. Recent successes include (a) the produc Brent Iverson

Kenneth Johnson
Professor in Chemistry & Biochemistry
Roger J. Williams Centennial Professor In Biochemistry
Email
web site
Three polymerases and a molecular motor: In projects related to AIDS, we examine HIV reverse transcriptase mechanism, its resistance to nucleoside analogs, and characterization of novel nonnucleoside inhibitor Kenneth Johnson

Adrian Keatinge-Clay
Assistant Professor in Chemistry & Biochemistry 

Email

Many important pharmaceuticals, including the antibiotic erythromycin and the immunosuppressant rapamycin, belong to a diverse class of molecules called polyketides. My lab uses protein crystallography and enzy Adrian Keatinge-Clay

Sean Kerwin
Associate Professor in Pharmacy
G. D. Searle Fellow
Email
web site
The long-term goal of our research is the development of selective strategies for the treatment of cancer, inflammation, and infectious diseases. Our work takes place at the interface of computational chemistr Sean Kerwin

G. Barrie Kitto
Professor in Chemistry & Biochemistry 

Email
web site

(1) Development of treatments and vaccines for AIDS. This research includes both the use of immunotoxins targeted to infected cells and a novel class of MHC-based vaccines. 

(2) Vaccines for Respirato

G. Barrie Kitto

Robert Krug
Chair, Molecular Genetics and Microbiology,
Lorene Morrow Kelley Fellow In Microbiology
Email
web site
The major focus of the Krug laboratory is the molecular biology of human influenza viruses (influenza A and B viruses), which cause widespread human disease. We are determining the molecular mechanisms of viral Robert Krug

Alan M. Lambowitz
Mr. & Mrs. A. Frank Smith, Jr. and Nancy Lee & Perry R. Bass Regents Chairs In Molecular Biology
Director, Institute for Cellular and Molecular Biology
Email
web site
Our laboratory studies gene expression, RNA splicing, catalytic RNAs, and retroviral-like genetic elements, including possible ancestors of HIV-1 and leukemia viruses. We are interested in mechanisms of RNA ca Alan M. Lambowitz

Hung-wen (Ben) Liu
George H. Hitchings Regents Chair In Drug Design
Professor of Medicinal Chemistry, Chemistry, and Biochemistry
Email
web site
My group is currently working on three general areas with the focus aimed at the elucidation of the mechanisms of novel enzymatic reactions and the design of methods to control and/or regulate their function Hung-wen (Ben) Liu

Edward Marcotte
Professor in Chemistry & Biochemistry
William and Gwyn Shive Endowed Professor in Metabolism and Bioinformatics
Email
web site
Our research group combines experimental approaches with computational/bioinformatics approaches to study protein function and protein-protein interactions on a genome-wide scale. We’ve discovered a number Edward Marcotte

Stephen Martin
Professor in Chemistry & Biochemistry
M. June and J. Virgil Waggoner Regents Chair In Chemistry
Email
web site
The design and synthesis of small molecules that exhibit high affinities for biomacromolecules is critical to the study of enzyme mechanism and specificity and to correlating structure and function in protein-l Stephen Martin

Mikhail Matz
Assistant Professor, Integrative Biology 

Email
web site

We are a molecular biology and genomics lab working on (i) biofluorescence and (ii) evolution in the marine environment. We address a wide range of issues, including: 

– molecular biology and

Mikhail Matz

Jennifer Maynard
Assistant Professor of Chemical Engineering 

Email
web site

Building on decades of basic research in the biological sciences, fundamental principles underlying the function of complex biological systems are being elucidated in laboratories throughout the world. Concurre Jennifer Maynard

Tanya Paull
Associate Professor in Molecular Genetics & Microbiology
Howard Hughes Medical Institute Investigator
Email
web site
Research in the lab is focused on the DNA damage response in eukaryotic cells, specifically the checkpoint activation and DNA repair responses that occur immediately after the introduction of chromosomal dou Tanya Paull

Austen Riggs
Professor of Biology 

Email
web site

Interactions between and within macromolecular assemblages are frequently the key to understanding many complex cellular processes. I am particularly interested in the molecular mechanisms responsible for pr Austen Riggs

Jon Robertus
Professor in Chemistry & Biochemistry
Benjamin Clayton Centennial Professor In Biochemistry
Email
web site
Research in my laboratory focuses on protein structure, action, engineering and rational drug design. This includes analysis of three-dimensional structure by X-ray crystallography, site-directed mutation of cl Jon Robertus

Krishnendu Roy
Associate Professor in Biomedical Engeering 

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web site

My overall research interest is in developing novel concepts for polymer controlled delivery of biological factors, especially for nucleic acid therapeutics (DNA, SiRNA and oligos) and stem cell engineering Krishnendu Roy

Rick Russell
Associate Professor in Chemistry & Biochemistry 

Email
web site

Our group combines biochemical and biophysical approaches to study the processes of RNA folding and assembly with proteins. Some of nature’s most complex and important enzyme machines are composed of RNA and pr Rick Russell

Christine Schmidt
Laurence E. McMakin Jr. Professor of Biomedical Engeering 

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web site

Damage to spinal cord and peripheral nerve tissue can have a devastating impact on the quality of life for individuals suffering from nerve injuries. Many attempts are being made to engineer therapies that can Christine Schmidt

Jason Shear
Professor in Chemistry & Biochemistry 

Email
web site

The Shear Group investigates complex cellular and biochemical microenvironments at a variety of levels. Several current projects are focused on development of novel sensor- array methods and electrophoretic a Jason Shear

Scott Stevens
Associate Professor of Molecular Genetics & Microbiology 

Email
web site

Ribonucleoproteins (RNPs) function in many cellular processes and the malfunction of some of these RNPs cause serious human disease. To better understand how disease states can be corrected, our laboratory stud Scott Stevens

Christopher Sullivan
Assistant Professor in Molecular Genetics and Microbiology 

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web site

The recent discovery of RNA interference (RNAi) and small regulatory RNAs such as siRNAs and miRNAs, has dramatically changed our understanding of the regulation of gene expression. Consequently, RNAi has gener Christopher  Sullivan

Lauren Webb
Assistant Professor in Chemistry & Biochemistry 

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Research in the Webb group seeks to understand and manipulate the mechanisms of interaction, organization, and self-assembly of biological macromolecules that lead to the complex and emergent properties of livi Lauren Webb

Marvin Whiteley
Assistant Professor Molecular Genetics and Microbiology 

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web site

Bacteria exhibit many social activities and represent a model for dissecting social behavior at the genetic level (recently defined as sociomicrobiology). One example of social behavior in bacteria is the use o Marvin Whiteley

Christian Whitman
Professor in Pharmacy, Medicinal Chemistry
Romeo T. Bachand, Jr. Regents Professorship In Pharmacy
Email
web site
My laboratory is interested in how enzymes evolve and how they work. We are studying two groups of enzymes, the tautomerase superfamily and the fumaryl acetoacetate hydrolase (FAH) superfamily. Both superfa Christian Whitman

Claus Wilke
Assistant Professor in Integrative Biology 

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web site

Wilke works in the areas of computational and theoretical biology. His research can be broadly subdivided into three areas: (1) molecular evolution, (2) evolution of RNA viruses, (3) theoretical population gene Claus Wilke

Whitney Yin
Assistant Professor in Chemistry & Biochemistry 

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web site

Our goal is to gain molecular insight in how transcription factors and RNA polymerase and DNA polymerase recognize special features of DNA and RNA, such as the promoters, termination sequences and origin of re Whitney Yin

Muhammad Zaman
Assistant Professor in Biomedical Engineering 

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web site

Research in my group is broadly focused on understanding how cancer cells interact with the extra cellular matrices in native environments. We use a combination of computational and experimental methods to stud Muhammad Zaman

Zhiwen (Jonathan) Zhang
Assistant Professor, in Pharmacy
Ph.D.
Email
web site
The goals of the Zhang lab include answering basic biological questions, developing novel biotechnologies, and identifying new drug therapies. We utilize both classic and novel techniques in the fields of bioch Zhiwen (Jonathan) Zhang

Yan Jessie Zhang
Assistant Professor in Chemistry & Biochemistry 

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A major focus of Zhang’s research is the elucidation of the fundamental principles of transcriptional regulation. The primary experimental approaches used in the laboratory are macromolecular structure determi Yan Jessie Zhang

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