Graduate students may complete their research under the direction of the members of the Biochemistry Graduate Studies Committee (GSC)
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| Eric V. Anslyn Distinguished Teaching Professor in Chemistry & Biochemistry Norman Hackerman Professorship in Chemistry web site |
Our research is oriented at developing artificial enzymes and sensors by synthetic and combinatorial library methods. Our synthetic projects are targeted to phosphodiester hydrolysis, enolate alkylations, and … |  |
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| Dean R. Appling Professor in Chemistry & Biochemistry Lester J. Reed Professor In Biochemistry web site |
My laboratory studies the organization and regulation of metabolic pathways in eukaryotes. Eukaryotic cells are composed of many different compartments, such as cytoplasm, mitochondria, and nuclei. Although ea… |  |
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| Karen S. Browning Associate Professor in Chemistry & Biochemistry Chairman, Cell & Molecular Biology Graduate Program and Director Dual Degree MD/PhD Program web site |
My research focuses on the initiation of protein synthesis in higher plants. We are seeking a molecular description of the process in which initiation factors (eIF4A, eIF4B, eIF4F, eIF3, eIF2 and PABP) select,… |  |
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| Richard Crooks Professor in Chemistry & Biochemistry Robert A. Welch Chair in Materials Chemistry web site |
Parallel replication of DNA and RNA arrays. We recently discovered a new method for replicating nucleic acid microarrays. Such arrays are presently used for genomic analysis, and within the next few years are e… |  |
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| Kevin Dalby Associate Professor of Pharmacy, Medicinal Chemistry |
Cancer is most commonly caused by the development of aberrant cell signaling pathways. Modern pharmaceutical research thus seeks a clear understanding of these pathways in efforts to treat this all too prevale… |  |
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| Andy Ellington Professor in Chemistry & Biochemistry Wilson M. and Kathryn Fraser Research Professor In Biochemistry web site |
The Ellington lab is primarily interesting in the evolutionary engineering of molecules, pathways, and organisms, and the application of these efforts to real world problems. In particular, we evolve functiona… |  |
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| Walter Fast Associate Professor of Pharmacy, Medicinal Chemistry |
We are interested in merging protein engineering technologies with more classical biochemical approaches in the investigation and manipulation of three enzyme systems: 1. Quorum sensing, a “language” that s… |  |
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| George Georgiou Professor in Chemical Engineering Cockrell Family Regents Chair in Engineering #9 web site |
Dr. Georgiou’s group is working on both biotechnology and mechanistic biology problems. In biotechnology, his group is focusing on the development of protein engineering and combinatorial library screening te… |  |
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| Marvin Hackert Professor in Chemistry & Biochemistry William Shive Centennial Professor In Biochemistry web site |
Our research focuses on understanding function of proteins in relationship to their three-dimensional structures. Antizyme and antizyme inhibitor are regulatory proteins of ornithine decarboxylase that initiate… |  |
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| David Hoffman Associate Professor in Chemistry & Biochemistry |
Biophysical methods such as nuclear magnetic resonance (NMR) spectroscopy and x-ray crystallography are extensively used in our investigations of protein and RNA structure and function. Current work includes t… |  |
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| Jon Huibregtse Professor in Molecular Genetics & Microbiology Graduate Advisor, Cell and Molecular Biology Graduate Program web site |
The Huibregtse lab studies the biochemistry of the ubiquitin proteolysis system, a major pathway for degradation of proteins in eukaryotic cells. Our interest in this pathway arose from study of human papilloma… |  |
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| Brent Iverson Distinguished Teaching Professor in Chemistry & Biochemistry Warren J. and Viola Mae Raymer Professor web site |
Antibody and enzyme engineering with an emphasis on creating better methods for improving protein function. Several new technologies have been developed and patented. Recent successes include (a) the produc… |  |
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| Kenneth Johnson Professor in Chemistry & Biochemistry Roger J. Williams Centennial Professor In Biochemistry web site |
Three polymerases and a molecular motor: In projects related to AIDS, we examine HIV reverse transcriptase mechanism, its resistance to nucleoside analogs, and characterization of novel nonnucleoside inhibitor… |  |
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| Adrian Keatinge-Clay Assistant Professor in Chemistry & Biochemistry |
Many important pharmaceuticals, including the antibiotic erythromycin and the immunosuppressant rapamycin, belong to a diverse class of molecules called polyketides. My lab uses protein crystallography and enzy… |  |
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| Sean Kerwin Associate Professor in Pharmacy G. D. Searle Fellow web site |
The long-term goal of our research is the development of selective strategies for the treatment of cancer, inflammation, and infectious diseases. Our work takes place at the interface of computational chemistr… |  |
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| G. Barrie Kitto Professor in Chemistry & Biochemistry |
(1) Development of treatments and vaccines for AIDS. This research includes both the use of immunotoxins targeted to infected cells and a novel class of MHC-based vaccines.
(2) Vaccines for Respirato… |
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| Robert Krug Chair, Molecular Genetics and Microbiology, Lorene Morrow Kelley Fellow In Microbiology web site |
The major focus of the Krug laboratory is the molecular biology of human influenza viruses (influenza A and B viruses), which cause widespread human disease. We are determining the molecular mechanisms of viral… |  |
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| Alan M. Lambowitz Mr. & Mrs. A. Frank Smith, Jr. and Nancy Lee & Perry R. Bass Regents Chairs In Molecular Biology Director, Institute for Cellular and Molecular Biology web site |
Our laboratory studies gene expression, RNA splicing, catalytic RNAs, and retroviral-like genetic elements, including possible ancestors of HIV-1 and leukemia viruses. We are interested in mechanisms of RNA ca… |  |
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| Hung-wen (Ben) Liu George H. Hitchings Regents Chair In Drug Design Professor of Medicinal Chemistry, Chemistry, and Biochemistry web site |
My group is currently working on three general areas with the focus aimed at the elucidation of the mechanisms of novel enzymatic reactions and the design of methods to control and/or regulate their function… |  |
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| Edward Marcotte Professor in Chemistry & Biochemistry William and Gwyn Shive Endowed Professor in Metabolism and Bioinformatics web site |
Our research group combines experimental approaches with computational/bioinformatics approaches to study protein function and protein-protein interactions on a genome-wide scale. We’ve discovered a number … |  |
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| Stephen Martin Professor in Chemistry & Biochemistry M. June and J. Virgil Waggoner Regents Chair In Chemistry web site |
The design and synthesis of small molecules that exhibit high affinities for biomacromolecules is critical to the study of enzyme mechanism and specificity and to correlating structure and function in protein-l… |  |
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| Mikhail Matz Assistant Professor, Integrative Biology |
We are a molecular biology and genomics lab working on (i) biofluorescence and (ii) evolution in the marine environment. We address a wide range of issues, including:
– molecular biology and … |
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| Jennifer Maynard Assistant Professor of Chemical Engineering |
Building on decades of basic research in the biological sciences, fundamental principles underlying the function of complex biological systems are being elucidated in laboratories throughout the world. Concurre… |  |
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| Tanya Paull Associate Professor in Molecular Genetics & Microbiology Howard Hughes Medical Institute Investigator web site |
Research in the lab is focused on the DNA damage response in eukaryotic cells, specifically the checkpoint activation and DNA repair responses that occur immediately after the introduction of chromosomal dou… |  |
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| Austen Riggs Professor of Biology |
Interactions between and within macromolecular assemblages are frequently the key to understanding many complex cellular processes. I am particularly interested in the molecular mechanisms responsible for pr… |  |
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| Jon Robertus Professor in Chemistry & Biochemistry Benjamin Clayton Centennial Professor In Biochemistry web site |
Research in my laboratory focuses on protein structure, action, engineering and rational drug design. This includes analysis of three-dimensional structure by X-ray crystallography, site-directed mutation of cl… |  |
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| Krishnendu Roy Associate Professor in Biomedical Engeering |
My overall research interest is in developing novel concepts for polymer controlled delivery of biological factors, especially for nucleic acid therapeutics (DNA, SiRNA and oligos) and stem cell engineering… |  |
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| Rick Russell Associate Professor in Chemistry & Biochemistry |
Our group combines biochemical and biophysical approaches to study the processes of RNA folding and assembly with proteins. Some of nature’s most complex and important enzyme machines are composed of RNA and pr… |  |
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| Christine Schmidt Laurence E. McMakin Jr. Professor of Biomedical Engeering |
Damage to spinal cord and peripheral nerve tissue can have a devastating impact on the quality of life for individuals suffering from nerve injuries. Many attempts are being made to engineer therapies that can… |  |
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| Jason Shear Professor in Chemistry & Biochemistry |
The Shear Group investigates complex cellular and biochemical microenvironments at a variety of levels. Several current projects are focused on development of novel sensor- array methods and electrophoretic a… |  |
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| Scott Stevens Associate Professor of Molecular Genetics & Microbiology |
Ribonucleoproteins (RNPs) function in many cellular processes and the malfunction of some of these RNPs cause serious human disease. To better understand how disease states can be corrected, our laboratory stud… |  |
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| Christopher Sullivan Assistant Professor in Molecular Genetics and Microbiology |
The recent discovery of RNA interference (RNAi) and small regulatory RNAs such as siRNAs and miRNAs, has dramatically changed our understanding of the regulation of gene expression. Consequently, RNAi has gener… |  |
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| Lauren Webb Assistant Professor in Chemistry & Biochemistry |
Research in the Webb group seeks to understand and manipulate the mechanisms of interaction, organization, and self-assembly of biological macromolecules that lead to the complex and emergent properties of livi… |  |
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| Marvin Whiteley Assistant Professor Molecular Genetics and Microbiology |
Bacteria exhibit many social activities and represent a model for dissecting social behavior at the genetic level (recently defined as sociomicrobiology). One example of social behavior in bacteria is the use o… |  |
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| Christian Whitman Professor in Pharmacy, Medicinal Chemistry Romeo T. Bachand, Jr. Regents Professorship In Pharmacy web site |
My laboratory is interested in how enzymes evolve and how they work. We are studying two groups of enzymes, the tautomerase superfamily and the fumaryl acetoacetate hydrolase (FAH) superfamily. Both superfa… |  |
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| Claus Wilke Assistant Professor in Integrative Biology |
Wilke works in the areas of computational and theoretical biology. His research can be broadly subdivided into three areas: (1) molecular evolution, (2) evolution of RNA viruses, (3) theoretical population gene… |  |
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| Whitney Yin Assistant Professor in Chemistry & Biochemistry |
Our goal is to gain molecular insight in how transcription factors and RNA polymerase and DNA polymerase recognize special features of DNA and RNA, such as the promoters, termination sequences and origin of re… |  |
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| Muhammad Zaman Assistant Professor in Biomedical Engineering |
Research in my group is broadly focused on understanding how cancer cells interact with the extra cellular matrices in native environments. We use a combination of computational and experimental methods to stud… |  |
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| Zhiwen (Jonathan) Zhang Assistant Professor, in Pharmacy Ph.D. web site |
The goals of the Zhang lab include answering basic biological questions, developing novel biotechnologies, and identifying new drug therapies. We utilize both classic and novel techniques in the fields of bioch… |  |
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| Yan Jessie Zhang Assistant Professor in Chemistry & Biochemistry |
A major focus of Zhang’s research is the elucidation of the fundamental principles of transcriptional regulation. The primary experimental approaches used in the laboratory are macromolecular structure determi… |  |